Earlier Independent Scientific Review
The following summaries describe earlier independent reviews of chlorpyrifos, documenting prior health and safety evaluations and consistent scientific and regulatory support for registered uses of the product.
WHO/FAO Joint Meeting on Pesticide Residues Panel (1999)
The World Health Organization (WHO) panel conducted a complete toxicological reevaluation of chlorpyrifos during periodic review of the product related to European standards for pesticide residues on food (Codex maximum residue limits or MRLs). Panel members included experts from a number of national regulatory authorities including the United Kingdom, the United States, Italy and Australia. The review confirmed an acceptable daily intake (ADI) for chlorpyrifos of 10 mg/kgBW/day (that is,10,000 nanograms per kilogram per body weight per day) and an acute reference dose of 0.1 mg/kgBW (that is, 100,000 nanograms per kilogram per body weight per day). A copy of the final monograph published by WHO is available.
Chlorpyrifos Reference Dose Panel (1997)
Composed of international health and medical experts in fields associated with neurotoxicology, and convened with support (funding) from Dow AgroSciences, the panel evaluated the published scientific literature and unpublished study reports from Dow AgroSciences related to chlorpyrifos and human safety. With observers present from U.S. EPA and the Canadian Pest Management Regulatory Agency, the panel recommended a chronic reference dose for chlorpyrifos of .01 mg/kgBW/day (that is,10,000 nanograms per kilogram per body weight per day) and an acute reference dose of .05 mg/kgBW/day (that is, 50,000 nanograms per kilogram of body weight per day). A copy of the final report was published in the Journal of Toxicology and Environmental Health, Part B, Volume 2, pages 211-255 (1999) and is available from the publisher.
Chlorpyrifos Epidemiology Panel (1997)
Convened to evaluate the scientific literature on human health and chlorpyrifos and identify areas where regulatory assessments of the product could be improved by further research, the panel included epidemiology, toxicology, and medical experts, and was sponsored (funded) by Dow AgroSciences in cooperation with U.S. EPA. A copy of the final report was published in the Journal of Toxicology and Environmental Health, Part B, Volume 2, pages 301-324 (1999) and is available from the publisher.
